Opportunity Information: Apply for RFA AG 19 026
The National Institutes of Health (NIH) funding opportunity titled "Development of Personalized In Vitro Assays to Quantitatively Assess Age-related Changes in Cellular Resiliencies to Physiologic Stressors" (Funding Opportunity Number RFA-AG-19-026) is a discretionary grant program aimed at supporting Small Business Technology Transfer (STTR) projects under the R41/R42 mechanism. The focus is on creating and moving toward commercialization standardized, quantitative, in vitro laboratory assays that can measure "resilience" at the cellular level, particularly as it changes with aging. In practical terms, the NIH is looking for tools that can expose cells to defined physiologic stressors in a controlled setting and then measure how well those cells withstand, respond to, and recover from those stressors, producing metrics that can be compared across individuals, timepoints, and laboratories.
A central theme of this FOA is personalization and standardization at the same time. The personalization aspect implies assays that can reflect an individual person's biology, for example by using donor-derived cells or other individualized cellular models. The standardization aspect emphasizes that the resulting assay platforms should be robust, reproducible, and suitable for broad use, meaning they should be designed with clear operating procedures, consistent reagents and readouts, and performance characteristics that can support eventual product development and adoption by the research or clinical-adjacent marketplace. The NIH interest is not simply exploratory biology; it is geared toward assay development with a pathway to commercialization, which is why the opportunity is structured as an STTR (requiring a small business to formally collaborate with a nonprofit research institution).
The opportunity is explicitly labeled "Clinical Trial Not Allowed," signaling that the supported work should not involve clinical trial activities. Instead, it is intended to support preclinical, lab-based assay development and validation work that can quantitatively assess cellular resilience. The kinds of outputs that would align with the announcement are assay systems, measurement methods, and standardized workflows that can evaluate cellular responses to physiologic stressors relevant to aging biology, and that can detect age-related changes in how cells cope with those stressors. The overall goal is to enable consistent measurement of resilience in vitro, making it easier to compare results across studies and potentially to support future interventions research by providing reliable cellular readouts.
Eligibility is limited to small businesses applying through the STTR program. Foreign institutions (non-U.S. entities) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible as applicant components. However, "foreign components" may be allowable when they meet the NIH definition in the NIH Grants Policy Statement, meaning certain discrete parts of the project could potentially be performed outside the United States if they are justified and permitted under NIH policy, even though the applicant organization itself must be U.S.-based and eligible.
From an administrative standpoint, the agency is the National Institutes of Health, the funding instrument is a grant, and the activity category falls under health. The associated CFDA number listed is 93.866. The opportunity was created on 2018-10-25 and had an original closing date of 2019-03-08. The provided source data does not specify an award ceiling or the expected number of awards, so those details would typically need to be confirmed by reviewing the full FOA text or related NIH budget guidance for that solicitation.
In summary, this FOA supports U.S. small business-led STTR projects to develop, standardize, and commercialize in vitro cellular assays that quantitatively measure resilience to physiologic stressors and can capture age-related changes. The work is intended to stay on the assay development and validation side rather than involving clinical trials, with an emphasis on generating reproducible, product-ready measurement approaches that can be broadly useful in aging and resilience research.Apply for RFA AG 19 026
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of Personalized In Vitro Assays to Quantitatively Assess Age-related Changes in Cellular Resiliencies to Physiologic Stressors (R41/R42 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2018-10-25.
- Applicants must submit their applications by 2019-03-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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