Opportunity Information: Apply for PA 17 461
The National Institutes of Health (NIH) funding opportunity titled "Symptom Cluster Characterization in Chronic Conditions (R21)" (Funding Opportunity Number PA-17-461) is a discretionary grant program designed to support early-stage, exploratory research focused on how symptoms co-occur and interact in people living with chronic conditions. The central goal is to encourage both preclinical and clinical studies, as well as secondary analyses of existing datasets, that can characterize symptom clusters in ways that ultimately inform better treatments and interventions. The intent is practical and patient-centered: by understanding patterns of multiple, overlapping symptoms (rather than studying each symptom in isolation), researchers can generate evidence that leads to improved functional outcomes and a better quality of life for individuals managing long-term health problems.
This opportunity uses the NIH R21 mechanism, which typically emphasizes innovative, high-impact ideas that may still be in the formative stages. Projects funded under this initiative are expected to contribute to clearer definitions, measurement strategies, and analytic approaches for identifying symptom clusters, and to show how those clusters relate to meaningful outcomes such as daily functioning, symptom burden, disability, treatment response, and overall well-being. Importantly, the program explicitly welcomes secondary data analysis, meaning applicants can propose rigorous studies that leverage previously collected clinical, observational, or other health-related datasets to discover or validate symptom cluster patterns without necessarily launching a brand-new cohort.
Eligibility is broad and includes many common applicant types such as state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; tribal organizations that are not federally recognized; nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible agencies of the federal government; faith-based and community-based organizations; regional organizations; Indian/Native American Tribal Governments that are not federally recognized; and U.S. territories or possessions.
At the same time, the announcement draws clear boundaries around foreign participation. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as applicant organizations, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, meaning a U.S.-based applicant may be able to include certain foreign collaborations or activities if they meet NIH policy requirements and are justified within the project.
From the administrative details provided, this is a grant (Funding Instrument Type: Grant) within the Education and Health funding activity category, associated with CFDA number 93.361, and administered by the NIH. The opportunity record shows an award ceiling of $200,000 and an original closing date of January 7, 2021, with a creation date of August 16, 2017. Overall, the program is aimed at accelerating research that clarifies how multiple symptoms group together in chronic illness and how those groupings can be used to design smarter, more effective interventions that improve real-world functioning and day-to-day quality of life.Apply for PA 17 461
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Symptom Cluster Characterization in Chronic Conditions (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361.
- This funding opportunity was created on 2017-08-16.
- Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "Symptom Cluster Characterization in Chronic Conditions (R21)".
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA-17-461.
What is the main purpose of this grant opportunity?
The purpose is to support early-stage, exploratory research that characterizes how symptoms co-occur and interact in people living with chronic conditions. The emphasis is on understanding patterns of multiple, overlapping symptoms (symptom clusters) to help inform better treatments and interventions and improve real-world outcomes such as functioning and quality of life.
What kind of research does the program encourage?
The program encourages preclinical studies, clinical studies, and secondary analyses of existing datasets that help define, measure, and analyze symptom clusters in chronic conditions.
Is this opportunity focused on single symptoms or multiple symptoms?
It is explicitly focused on multiple symptoms and how they cluster together, rather than studying each symptom in isolation.
What does "symptom cluster characterization" mean in the context of this opportunity?
Based on the description provided, it refers to research aimed at identifying and describing patterns of symptoms that tend to occur together in chronic conditions, determining how those symptoms interact, and developing clearer definitions, measurement strategies, and analytic approaches for detecting these clusters.
What outcomes are projects expected to relate symptom clusters to?
Projects are expected to connect symptom clusters to meaningful outcomes such as daily functioning, symptom burden, disability, treatment response, and overall well-being/quality of life.
What grant mechanism does this opportunity use?
This opportunity uses the NIH R21 mechanism.
What is generally emphasized by the NIH R21 mechanism (as described here)?
As described in the opportunity summary, the R21 mechanism typically emphasizes innovative, high-impact ideas that may still be in formative stages (early-stage, exploratory work).
Are secondary data analyses allowed under this program?
Yes. The program explicitly welcomes secondary data analysis, including rigorous studies that leverage previously collected clinical, observational, or other health-related datasets to discover or validate symptom cluster patterns.
Do applicants need to start a brand-new cohort or collect entirely new data?
Not necessarily. The description specifically notes that applicants may propose studies using previously collected datasets, meaning a brand-new cohort is not required in all cases.
What is the funding instrument type?
The funding instrument type is a Grant.
Which federal agency administers this grant?
This grant opportunity is administered by the National Institutes of Health (NIH).
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA 93.361.
What is the funding activity category listed for this opportunity?
The funding activity category is listed as Education and Health.
Who is eligible to apply?
Eligibility is broad and includes, as described: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; tribal organizations that are not federally recognized; nonprofit organizations (with or without 501(c)(3) status, as long as they are not institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other eligible entities.
Are minority-serving institutions mentioned as eligible?
Yes. The announcement highlights additional eligible applicant categories including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The eligible categories listed include faith-based and community-based organizations.
Are U.S. territories or possessions eligible to apply?
Yes. The eligible categories listed include U.S. territories or possessions.
Are federal government agencies eligible to apply?
Yes. The eligible categories listed include eligible agencies of the federal government.
Can a foreign organization apply as the applicant organization?
No. The announcement states that non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as applicant organizations.
Can a non-domestic component of a U.S. organization apply?
No. The announcement states that non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed in any way?
Yes. The announcement notes that foreign components are allowed as defined by the NIH Grants Policy Statement, meaning a U.S.-based applicant may be able to include certain foreign collaborations or activities if they meet NIH policy requirements and are appropriately justified.
What is the award ceiling listed for this opportunity?
The opportunity record shows an award ceiling of $200,000.
What is the original closing date shown in the record?
The original closing date shown is January 7, 2021.
When was this opportunity record created?
The creation date listed is August 16, 2017.
What is the overall practical intent of the program?
The intent is described as practical and patient-centered: by understanding symptom cluster patterns in chronic illness, researchers can generate evidence that supports smarter interventions aimed at improving functional outcomes and day-to-day quality of life.
Browse more opportunities from the same category: Education, Health
Next opportunity: Electronic Nicotine Delivery Systems (ENDS): Population, Clinical and Applied Prevention Research (R21)
Previous opportunity: Research to Support the Reduction and Elimination of Mental Health Disparities (Admin Supp)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 17 461
Applicants also applied for:
Applicants who have applied for this opportunity (PA 17 461) also looked into and applied for these:
| Funding Opportunity |
|---|
| Biology of Lung, and Head and Neck Preneoplasias (R21) Apply for PA 17 460 Funding Number: PA 17 460 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Stimulating Access to Research in Residency (StARR) (R38) Apply for RFA HL 18 023 Funding Number: RFA HL 18 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: $221,000 |
| Clinical and Epidemiological Research on Chronic Disease in the Caribbean (R01) Apply for PAR 17 470 Funding Number: PAR 17 470 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Electronic Nicotine Delivery Systems (ENDS): Population, Clinical and Applied Prevention Research (R21) Apply for PAR 17 472 Funding Number: PAR 17 472 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Electronic Nicotine Delivery Systems (ENDS): Population, Clinical and Applied Prevention Research (R01) Apply for PAR 17 473 Funding Number: PAR 17 473 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes (U01) Apply for RFA CA 17 041 Funding Number: RFA CA 17 041 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploiting HIV and/or Host Genomic Information to Understand HIV Compartments or Reactivation in Individuals with Substance Use Disorders (R61/R33) Apply for RFA DA 18 016 Funding Number: RFA DA 18 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $650,000 |
| NINR Center of Excellence (P30) Apply for RFA NR 17 004 Funding Number: RFA NR 17 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Short-term Mentored Career Enhancement Awards for Mid-Career Investigators to Integrate Basic Behavioral and Social Sciences (K18) Apply for PAR 17 486 Funding Number: PAR 17 486 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| New Onset Depressive Symptoms in Acute Illness (R01 Clinical Trial Not Allowed) Apply for PA 17 488 Funding Number: PA 17 488 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| New Onset Depressive Symptoms in Acute Illness (R21 Clinical Trial Not Allowed) Apply for PA 17 487 Funding Number: PA 17 487 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Addressing Chronic Wound Trajectories Through Social Genomics Research (R01 Clinical Trial Optional) Apply for PA 17 492 Funding Number: PA 17 492 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Implementing the Most Successful Interventions to Improve HIV/AIDS Outcomes in U.S. Communities (R01 Clinical Trial Optional) Apply for PAR 17 491 Funding Number: PAR 17 491 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Analyzing and Interpreting Clinician and Patient Adverse Event Data to Better Understand Tolerability (U01) Apply for RFA CA 17 052 Funding Number: RFA CA 17 052 Agency: National Institutes of Health Category: Education, Health Funding Amount: $425,000 |
| Pediatric Immunotherapy Translational Science Network (PI-TSN)(U54) Apply for RFA CA 17 050 Funding Number: RFA CA 17 050 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,600,000 |
| Pediatric Immunotherapy Translational Science Network (PI-TSN)(U01) Apply for RFA CA 17 051 Funding Number: RFA CA 17 051 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Implementing the Most Successful Interventions to Improve HIV/AIDS Outcomes in U.S. Communities (R21 Clinical Trial Optional) Apply for PAR 17 490 Funding Number: PAR 17 490 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Addressing Chronic Wound Trajectories Through Social Genomics Research (R21 Clinical Trial Optional) Apply for PA 17 493 Funding Number: PA 17 493 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| NCI Outstanding Investigator Award (R35) Apply for PAR 17 494 Funding Number: PAR 17 494 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Innovative Molecular Analysis Technology Development for Cancer Research and Clinical Care (R43/R44 Clinical Trial Not Allowed) Apply for PAR 18 303 Funding Number: PAR 18 303 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 17 461", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.